Retooling for Human Gene Therapy: New and Improved Adenoviral Vectors

Dr Juliana Small of the University of Pennsylvania, Drs Raj Kurupati, Xianqyang Zhou and their colleagues from the Wistar Institute have developed a novel adenoviral vector for delivery of multiple transgenes.

Gene therapy using an adenovirus vector: a new gene is injected into an adenovirus vector, which is used to introduce the modified DNA into a human cell; if the treatment is successful, the new gene will make a functional protein. Image credit: U.S. National Library of Medicine.
With the genetic basis of a number of human diseases known, many attempts have been made to treat the disorders by adding back the correct genetic information to individual cells. Adding foreign genetic material to treat disorders comes under the realm of gene therapy.
Conceptualiz… Read more

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